Ryannon K. Frederick serves as Chief Nursing Officer at Mayo Clinic, where she leads transformative initiatives that elevate nursing practice and shape health care delivery across the enterprise. She has pioneered nurse-led advancements that enhance patient care and remove systemic barriers, driving innovation in care team models and global nursing collaborations. Her leadership has supported nurses in developing and advancing their own clinical studies, and she has championed scalable artificial intelligence solutions and enterprise-wide platforms for staff innovation resulting in patent-pending concepts and measurable improvements in patient experience. Ms. Frederick’s strategic vision has positioned Mayo Clinic nursing as a central force in advancing the profession both locally and globally. Through strategic partnerships, she has prioritized nursing expertise in technology development and restored human-centered care through ambient documentation models. Her contributions to national forums reflect a deep commitment to knowledge-sharing, amplifying the voice of nurses, and building collective impact across disciplines. She earned her MSN from the University of Minnesota and BSN from the University of Iowa.